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Sagonowsky 2021)

Instead, a historical cohort study of over 200,000 electronic health records found a reduced association between semaglutide use and suicidality in both people with T2DM and obesity at 1 year 209

For example, in the CREDENCE trial (Canagliflozin and Renal Events in Diabetes with Established Nephropathy Clinical Evaluation trial), the residual risk of the primary composite outcome event of ESKD, doubling of serum creatinine, or renal or CV death with canagliflozin was 11.1% [11, 14]

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